【摘 要】
：
Pyrazolones and Pyrazolone derivatives have been widely applied to the synthesis of many drugs.[1] For example,edaravone(3-methyl-1-phenyl-2-pyrazolin-5-one)has been developed as a medical drug for br
【机 构】
：
College of Chemistry and Molecular Engineering,Zhengzhou University,Zhengzhou,Henan 450052,China
【出 处】
：
中国化学会全国第十二届有机合成化学学术研讨会
论文部分内容阅读
Pyrazolones and Pyrazolone derivatives have been widely applied to the synthesis of many drugs.[1] For example,edaravone(3-methyl-1-phenyl-2-pyrazolin-5-one)has been developed as a medical drug for brain ischrmia.[2] Due to the importance of biological activities of Pyrazolone compounds,the development of asymmetric methods to synthesize Pyrazolonederivatives is very interesting.[3] In recent years,different research groups have developed asymmetric synthesis methods of Pyrazolone derivatives.[1,3] However,the catalystic system for this kind of reaction is organocatalysis,few metal catalytic system has been developed.Our labouratory mainly researches asymmetric reactions,which are catalysted by dinuclear zinc catalyst.[4] Herein,the asymmetric Michael addition reaction of 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one to nitroalkenes is catalysted by dinuclear zinc catalyst.It gives the corresponding products in good yield with general diastereoselectivity and enantioseletivity.
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