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Cancer stem cells (CSCs),are known to be resistant to chemotherapy and radiotherapy and are associated with tumor metastasis and recurrence after treatnents,which attracted increasing attention with regard to the development of advanced therapeutic methods [1].However,evidence exists indicating that non-CSCs in the tumor can spontaneously and stochastically turn into CSCs de novo.Hence,it.is cru cial to eliminate CSCs and non-CSCs simultaneously for effective cancer therapy.