【摘 要】
：
Aim: To investigate the relationship between cerebroprotection of pinocembrin and epoxyeicosatrienoic acids (EETs) and their regulating enzyme soluble epoxide hydrolase (sEH).Methods: Rats underwent m
【机 构】
：
Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
论文部分内容阅读
Aim: To investigate the relationship between cerebroprotection of pinocembrin and epoxyeicosatrienoic acids (EETs) and their regulating enzyme soluble epoxide hydrolase (sEH).Methods: Rats underwent middle cerebral artery occlusion (MCAO) to mimic permanent focal ischemia, and pinocembrin was administered via tail vein injection at 10 rmin, 4, 8, and 23 h after MCAO.After 24 h MCAO, rats were re-anesthetized, and the blood and brain were harvested and determined.
其他文献
Aim: DDPH (1-(2,6-dimethylphenoxy)-2-(3, 4-dimethoxyphenylethylamino) propane hydrochloride), a candidate drug known to be an a1-adrenoceptor antagonist,can efficiently penetrate through blood brain b
Aim: This study was to investigate the role of IL-1β in the enhanced seizure susceptibility after prolonged febrile seizures (FSs).Methods: Rats or mice pups (P8) were exposed to a hyperthermal chambe
Aim: Ca/calmodulin-dependent protein kinase (CaMKII) was a critical molecule for the regulation of the wake-sleep cycle.The level of CaMKII phosphorylation (pCaMKII) was positively related with the to
Aim: Amyloid plaques in the extracellular parenchyma mainly consist of amyloid-β peptides (Aβ), one of the pathological hallmarks in Alzheimers disease (AD).In the present study, we examined neuroinfl
G-protein-coupled receptor 30 (GPR30)/G-protein-coupled estrogen receptor is a novel estrogen membrane receptor that localizes to the cell membrane and endoplasmic reticulum.GPR30 is widely distribute
Aim: Growing evidence indicates a relationship between dopamine system and depression, and some dopamine receptor agonists have been proved to produce antidepressant effects.The dopamine receptor that
Aim: To study the effect of catalpol on hypothalamus-pituitary-adrenal axis (HPA) disturbance of AD (Alzheimers disease) rats.Methods: Rats were injected fragment 25-35 of Aβ (β-amyloid protein, Aβ) i
Aim: Cerebral ischemia/reperfusion injury induces alterations in many signaling pathways that underlie BBB disruption and lead to neurovascular damage.We investigated the mechanisms of occludin degrad
Aim: To investigate the protective effects of noble dendrobium polysaccharides (NDP) on lipopolysaccharide (LPS)-induced learning and memory deficits in rats, and explore the possible mechanisms.Metho
Aim: Hyperphosphorylation of tau mediated by mTOR/p70S6K pathway has been thought to contribute to cognitive dysfunction of Alzheimers disease.Whether mTOR/p70S6K signaling is also involved in cogniti