Folate-conjugated biodegradable core cross-linked polyphosphoester micelles for targeted and pH-trig

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户:z58119366
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Polymeric micelles,self-assembled from amphiphilic block copolymers in aqueous medium with a nanoscopic size range,have been regarded as one of the most commonly used anti-cancer drug delivery systems.The applications of polymeric micelles,however,have been hampered by their poor in vivo stability,which leads to micellar dissociation and premature release of encapsulated drugs [1].
其他文献
The deposition of drug particles in the respiratory tract is closely related to their aerodynamic diameter.Generally,only those particles with the size less than 7 μm can be inhaled into the lower res
Self-assembled nanoparticles composed of amphiphilic block copolymers can efficiently encapsulate hydrophobic anticancer drugs into the hydrophobic core.As demonstrated in the phase 1 clinical data of
Calcium phosphate (CaP) precipitates were developed as a transfection method for DNA in the 1970s [1].This procedure is very attractive because of its biocompatibility,economic materials,ease of prepa
Hypertrophic scarring (HS) is a pathological wound healing process,which is mainly due to the abnormal metabolism of collagen and excessive microvessel formation.Generally,this process reaches a peak
Islet transplantation is one of the therapeutic approach for diabetic patients.For an average-size person (70 kg),a typical transplant requires about one million islets,isolated from two donor pancrea
Multidrug resistance (MDR) is always an impediment to successful chemotherapy and considerable efforts have been devoted to reverse MDR including designing various functional drug delivery systems (DD
The past two decades have been packed with the development of a new bio-nano-material called microfibrillated cellulose (MFC).Simply obtained by a strong fibrillation of the cellulosic fibers,MFC cons
Gold nanoparticles gained attention as attractive materials for delivery system,optical sensing,and phototherapy [1].Recently,polymeric nanoparticles combined with gold nanoparticles have been suggest
Precisely diagnosis and effective therapy of cancer have attracted much attention due to its high mortality.Therefore,a myriad of nanocarriers incorporating bioactivc molecules has been engineered for
Currently,how to enhance anti-cancer efficacy but reduce side effects is a major challenge for cancer chemotherapy [1].In the present study,pH-sensitive Dextran-Retinal (Dex-RAL) nanoparticles were pr