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目的评价对原发性帕金森病,实施双侧丘脑底核脑深部电刺激(DBS)治疗的疗效。方法对6例帕金森病患者采用磁共振导向立体定向方法,将刺激电极分别植入双侧丘脑底核,同期植入刺激发生器。术后1个月用程控仪在体外调整刺激参数,以达到最佳疗效。结果6例患者术后均获得了显著的疗效,震颤完全消失,肌强直、步态、姿势障碍以及药物所致的并发症明显改善,同时多巴胺类药物用量明显减少。结论DBS治疗PD,具有安全,可逆转、疗效显著等优点,因观察时间短,长期疗效有待进一步观察。
Objective To evaluate the efficacy of bilateral deep treatment of bilateral subthalamic nuclei (DBS) on primary Parkinson’s disease. Methods Six patients with Parkinson’s disease were treated with magnetic resonance guided stereotactic method. The stimulation electrodes were implanted into the bilateral subthalamic nuclei, and the stimulator was implanted at the same time. One month after operation, adjust the stimulation parameters in vitro with a programmed controller to achieve the best therapeutic effect. Results All the 6 patients achieved significant curative effect after operation. Tremor disappeared completely. Myotonia, gait, postural disorders and drug-induced complications were significantly improved. At the same time, the dosage of dopamine was significantly decreased. Conclusion The treatment of PD with DBS is safe, reversible and has obvious curative effect. Due to the short observation time, the long-term curative effect needs to be further observed.