pH-Sensitive Nanoformulated Triptolide as a Targeted Therapeutic Strategy for Hepatocellular Carcino

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：chrisliuyaqin

【摘要】

：

　　Objective: we work on the designed synthesis of a tumor-responsive nanoformulated triptolide (Nf-Trip)for HCC targeted therapy, which is delivered specifica

【作者】

：

ShuaifeiWang;DaishunLin;

【机构】

：

College of Pharmaceutical Science, Zhejiang University, Hangzhou, 310058

【出处】

：

2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会

【发表日期】

：

2015年期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Objective: we work on the designed synthesis of a tumor-responsive nanoformulated triptolide (Nf-Trip)for HCC targeted therapy, which is delivered specifically to tumor cells.Methods: Nf-Trip is composed of natural triptolide and two polymers synthesized from generally recognized as safe (GRAS) materials;One polymer is pluronic F127 esterified with folic acid and the other is a synthetic 10-mer of aspartic acid with an octadecylamine tail and ionizable imidazole side chains for pH sensitivity.

其他文献

Molecularly imprinted nanoparticles targeting the lipopolysaccharides of Pseudomonas aeruginosa

　　Here, we report the preparation of molecularly imprinted polyacrylamide nanoparticles that specifically recognize the gram-negative bacterium and human path

会议

Construction and mechanism of a novel redox-responsive paclitaxel conjugate for efficacy intracellul

　　Polymer-drug conjugates have demonstrated significant potentials for the delivery of active agents to targets with minimal burst effect during transition.In

会议

A novel pharmacokinetic model based on the complex elimination of monoclonal antibodies for bevacizu

　　Background and Purpose: The complex pharmacokinetic (PK) properties of monoclonal antibody (mAb) including a nonlinear pharmacokinetics and a significant in

会议

Exploring impacts of different regeneration conditions of the cation exchange resin on Mulberry alka

　　As the main active alkaloids of mulberry, 1-deoxynojirimycin (1-DNJ, pKa=7.53), and its analogues fagomine (pKa=8.4), 1, 4-dideoxy-1, 4-imino-D-arabinitol (

会议

Hybrid Polyaniline-Lipid Nanoparticles for Targeted Photothermal Cancer Therapy

会议

Formulation and Evaluation of Podophyllotoxin-Loaded Glycyrrhizic Acid Micelles for Dermal Delivery

　　As the first-line agent for genital warts, Podophyllotoxin (POD) could induce extensively dermal burning, itching, and erythema.Meanwhile, as a common anti-

会议

Serum Tolerance of Polyelectrolyte Brushes/survivin-siRNA Polyplex Enhance the Efficacy of Cisplatin

　　RNAi-based technology holds great promise in the treatment of cancer and viral infections.Currently cationic polyelectrolytes are typically used to improve

会议

Analysis and identification of the degradation products of baicalein by HPLC-MS/MS method

会议

The research of in vitro oral insoluble drug release from hydrophilic matrix tablets containing poly

　　The research of prolonged release preparation is still a hot topic in the study of drug delivery systems (DDS).Among them hydrophilic matrix tablets contain

会议

Preparation and characterization of poorly water-soluble drug glipizide solid dispersions using hot-

　　The study is aim to prepare and characterize solid dispersions of poorly water-soluble drug glipizide with the intention to improve the dissolution rates.Th

会议

pH-Sensitive Nanoformulated Triptolide as a Targeted Therapeutic Strategy for Hepatocellular Carcino

与本文相关的学术论文