In the past decades,a great deal of effort has been devoted to the development of aminocarbonylation reactions due to the significant role amide played in biological systems as well as in the fields of natural products,pharmaceuticals,and polymers.Among them,palladium-catalyzed aminocarbonylation from aryl halides,primary or secondary amines and carbon monoxide is a powerful and most frequently used method in organic synthesis.However,this approach is fraught with troublesome handling of hazardous carbon monoxide gas,high pressure,high temperature,and other harsh reaction conditions.Herein,we have developed a series of synthetic approaches for amide using carbamoylsilanes as a source of the carbamoyl groups,including the palladium-catalyzed aminocarbonylation of halides with carbamoylsilane,addition of carbamoylsilanes to the C=N bond of imines,addition of carbamoylsilanes to the C=O bond of aldehydes and selective C-H functionalization reactions on the electron-deficient aromatics.