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  5. Chimaeric polymersomes based on poly(ethylene glycol)-b-poly(L-leucine)-b-poly(L-glutamic acid) for

Chimaeric polymersomes based on poly(ethylene glycol)-b-poly(L-leucine)-b-poly(L-glutamic acid) for

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：du_go666
【摘 要】
：
Synthetic polypeptides inherit many intriguing properties of proteins such as excellent biocompatibility,biodegradability,and unique hierarchical assembly property,and thus have been extensively devel
【作 者】
：
Peipei Chen Chao Deng Fenghua Meng Jian Zhang Ru Cheng Zhiyuan Zhong 
【机 构】
：
Biomedical Polymers Laboratory,and Jiangsu Key Laboratory of Advanced Functional Polymer Design and
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
【发表日期】
：
2014年6期
【关键词】
：
polypeptide chimaeric polymersome pH-responsive intracellular release 
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　　Synthetic polypeptides inherit many intriguing properties of proteins such as excellent biocompatibility,biodegradability,and unique hierarchical assembly property,and thus have been extensively developed for drug delivery and tissue engineering [1-2].In this study,novel chimaeric polymersomes with average hydrodynamic diameters of 54.4-71.6 nm were developed from poly(ethylene glycol)-b-poly(L-leucine)-b-poly(L-glutamic acid) (PEG-PLeu-PLG) triblock copolymers for efficient loading and intracellular release of doxorubicin hydrochloride (DOX·HCl).
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