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Ginsenoside Rg1,an active component of ginseng,has been shown to attenuate LPS-induced inflammatory responses in RAW267.4 macrophages,N9 microglia and murine BV-2 microglial cells.The purpose of this study was to investigate the protective effects of Rg1 on lipopolysaccharide(LPS)-induced astrocyte activation in primary cultures of midbrain astrocytes and the possible mechanism.