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  5. Active MERS-CoV replication and aberrant induction of inflammatory cytokines and chemokines in human

Active MERS-CoV replication and aberrant induction of inflammatory cytokines and chemokines in human

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：hfzwl
【摘 要】
：
Middle East respiratory syndrome coronavirus (MERS-CoV) caused severe pneumonia, multi-organ dysfunction and a higher fatality rate (50％ versus 10％) than severe acute respiratory syndrome coronavirus
【作 者】
：
ZHOU JIE 
【机 构】
：
The University of Hong Kong
【出 处】
：
中国免疫学会第九届全国免疫学学术大会
【发表日期】
：
2014年8期
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Middle East respiratory syndrome coronavirus (MERS-CoV) caused severe pneumonia, multi-organ dysfunction and a higher fatality rate (50％ versus 10％) than severe acute respiratory syndrome coronavirus (SARS-CoV).To understand the pathogenesis, we studied viral replication, cytokine/chemokine response and antigen presentation in MERS-CoVinfected human monocyte-derived macrophages (MDMs) versus SARS-CoV-infected-MDMs.Only MERS-CoV can replicate in MDMs.
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