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The Daphniphyllum alkaloids represent a huge and growing group of architecturally complex natural products and has recently become a hot topic for synthetic chemists.Daphenylline is the first member found to contain a tetrasubstituted arene ring fused with another three all-carbon rings which is unprecedented in Daphniphyllum alkaloids[1].Attracted by the structure novelty,we have developed Fridel-Crafts type Michael reaction[2] and [3+2] cycloaddition[3] strategies for ABCE skeleton and Diels-Alder/aromatization[4] strategy for DEF skeleton of dapheylline.