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  5. The Kv7/KCNQ channel blocker XE991 protects nigral dopaminergic neurons in the 6-hydroxydopamine rat

The Kv7/KCNQ channel blocker XE991 protects nigral dopaminergic neurons in the 6-hydroxydopamine rat

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：ljyxq13571302523
【摘 要】
：
The excitability of dopaminergic neurons in the substantia nigra pars compacta(SNc)that supply the striatum with dopamine determines the function of nigrostriatal system for motor coordination.Our pre
【作 者】
：
Haixia Liu Limin Shi Hong Jiang Junxia Xie 
【机 构】
：
Department of Physiology,Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurol
【出 处】
：
2016年国际生理学学术大会
【发表日期】
：
2016年6期
【关键词】
：
channel XE991 Parkinson's disease 6-hydroxydopamine dopaminergic neurons 
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　　The excitability of dopaminergic neurons in the substantia nigra pars compacta(SNc)that supply the striatum with dopamine determines the function of nigrostriatal system for motor coordination.Our previous study showed that 4-pyridinylmethyl-9(10H)-anthracenone(XE991),the specific blocker of Kv7/KCNQ channels,could enhance the excitability of nigral dopaminergic neurons,resulting in attenuation of Parkinsons disease(PD)catalepsy elicited by systemic haloperidol administration.
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