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  5. Combined contributions of impaired hepatic CYP2C11 and intestinal breast cancer resistance protein a

Combined contributions of impaired hepatic CYP2C11 and intestinal breast cancer resistance protein a

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：shion31208
【摘 要】
：
Aim: To evaluate the contribution of the impaired cytochrome P450 and breast cancer resistance protein (BCRP) activity and expression to drug pharmacokinetics under diabetic states.Methods: Diabetic w
【作 者】
：
Hai-yan LIU Xiao-dong LIU Li LIU Sen YU Jia LI Dan MEI Ru DUAN 
【机 构】
：
Jiangsu Chia Tai Tianqing Pharmaceutical Co Ltd, Nanjing 210023, China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
diabetes mellitus pharmacokinetics glibenclamide CYP2Cl1 breast cancer resistanc 
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Aim: To evaluate the contribution of the impaired cytochrome P450 and breast cancer resistance protein (BCRP) activity and expression to drug pharmacokinetics under diabetic states.Methods: Diabetic was induced in rats by intraperitoneal administration of streptozocin.Glibenclamide (GLB), a substrate of BCRP, served as a model drug.The pharmacokinetics of orally administered GLB (10 mg/kg) were studied.
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