论文部分内容阅读
：本研究组曾发现2-取代-3,4-二氢-1-异喹啉酮类和3-苄基-4-喹唑啉酮类化合物具有舒张血管的活性[1,2]。本课题合成了30 余种2-苄基-1-异喹啉酮类化合物,采用1H NMR 和HRMS表征目标化合物的结构。
2-苄基-1-异喹啉酮类舒张血管活性的研究
【摘 要】
：
：本研究组曾发现2-取代-3,4-二氢-1-异喹啉酮类和3-苄基-4-喹唑啉酮类化合物具有舒张血管的活性[1,2]。本课题合成了30 余种2-苄基-1-异喹啉酮类化合物,采用1H NMR 和HRMS表征目标化合物的结构。
【机 构】
：
西安交通大学药学院, 西安 710061 西安交通大学医学院, 西安 710061
【出 处】
：
2015年全国药物化学学术会议暨第五届中英药物化学学术会议
【发表日期】
：
2015年3期
其他文献
A series of novel 3-aminothiazolquinolones as newly structural antibacterial agents were designed and synthesized for the first time.
Hybrids of metronidazole and quinolones as antimicrobial agents were developed and their bioactive assay that the newly synthesized compounds exhibited good or even stronger antimicrobial activities a
Berberine-derived Benzimidazoles as New Potential Antimicrobial Agents:Design,Synthesis and Biologic
A series of novel berberine-derived benzimidazole derivatives and characterized by NMR,IR,MS and HRMS spectra.All the new compounds were screened for their antimicrobial efficacy against four Gram-pos
A series of naphthalimide nitrogen mustards as anticancer agents were developed,their structures were characterized by 1H NMR,13C NMR,IR,MS and HRMS spectra,and the single crystal of compound 4g was s
Infectious diseases caused by microbes are a serious public safety issues associated with significant mortality and health-care costs in world-wide.Hence,the development of alternative novel drugs is
Molecular hybridisation approach is an emerging tool in designing new drug molecules.
The emergence of multiple drug resistant microorganisms has caused major health concern worldwide.
A series of novel quinazolinone benzimidazolyl ethanols with dual-targeting actions were developed and characterized by NMR,IR,MS and HRMS spectra.
Quinolones are one of the most widely prescribed antimicrobial agents as they are generally well tolerated with excellent safety profile,favorable pharmacokinetic characteristics and broad antibacteri
A novel series of quinolone triazoles as antimicrobial agents were designed and synthesized,and their structures were characterized by 1H NMR,13C NMR,IR,MS and HRMS spectra.