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[目的]掌握江苏省灌云县病毒性脑膜炎流行的流行特征、影响因素和可能病因。[方法]采用统一的流行病学调查表对病例进行调查,收集2004年～2006年8月31日全县病毒性脑膜炎住院病例资料,进行流行病学及临床资料分析;采用1︰2配比病例对照研究的方法分析流行因素;24份脑脊液标本送江苏省疾控中心检测,并进行病毒分离。[结果]2004～2005年全县病毒性脑膜炎病例呈现散发状态;2006年1～8月份共查出病例数为465例,从6月份起出现疫情上升,出现流行,7月份达高峰;主要累及15岁以下儿童,占93.66%;男性多于女性,男女比为2.77︰1;主要临床症状体征为发热、头痛、呕吐、脑膜刺激征阳性、脑脊液有核细胞增多。饭前洗手与多吃瓜果为保护因素,说明该病与不良卫生习惯有关系。24份脑脊液经PCR检测,16份Echo30肠道病毒阳性。[结论]2006年夏季江苏省灌云县病毒性脑膜炎出现一次流行,致病病原体为Echo30肠道病毒,不良卫生习惯是导致该病发生流行的可能危险因素。
[Objective] To master the epidemiological characteristics, influencing factors and possible etiology of viral meningitis in Guanyun County of Jiangsu Province. [Methods] A unified epidemiological questionnaire was used to investigate the cases and the data of inpatients with viral meningitis from 2004 to August 31, 2006 were collected for epidemiological and clinical data analysis. The data of 1: 2 24 cases of cerebrospinal fluid samples were sent to Jiangsu CDC for detection and virus isolation. [Results] The cases of viral meningitis in 2004 ~ 2005 were exuded. From January to August 2006, the number of cases was 465 cases. Since June, the epidemic increased and became epidemic, reaching the peak in July. The main Involving children under the age of 15, accounting for 93.66%; more men than women, male to female ratio of 2.77: 1; the main clinical signs of fever, headache, vomiting, positive meningeal irritation, cerebrospinal fluid nucleated cells increased. Wash hands before meals and eat fruits as a protective factor, indicating that the disease and poor health habits are related. 24 cerebrospinal fluid were detected by PCR, 16 Echo30 enterovirus positive. [Conclusion] In the summer of 2006, a serious epidemic of viral meningitis was found in Guanyun County, Jiangsu Province. The pathogen was Echo30 enterovirus. Adverse health habits were the possible risk factors for the epidemic.