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目的探讨长托宁(通用名:盐酸戊乙奎醚注射液)在抢救急性有机磷农药中毒患者中的应用,为临床治疗该类患者提供依据。方法 2008年4月至2010年12月收治的41例急性有机磷中毒患者,按就诊顺序随机分为2组,长托宁组20例以长托宁+氯解磷定治疗,阿托品组21例以阿托品+氯解磷定治疗。对2组患者的疗效进行分析。结果长托宁组患者的临床表现消失时间〔(1.80±1.12)vs(3.12±1.15)d〕、住院时间〔(9.20±1.05)vs(12.34±3.60)d〕、反跳发生率〔10.00%vs38.10%)均明显低于阿托品组(P均<0.05)。长托宁组死亡1例,阿托品组死亡2例。结论长托宁治疗急性有机磷中毒疗效优于阿托品,病程短,副作用少,治愈率高,病死率低。
Objective To investigate the application of penehyclidine hydrochloride (common name: Penehyclidine Hydrochloride Injection) in the rescue of patients with acute organophosphorus pesticide poisoning, so as to provide basis for clinical treatment of such patients. Methods From April 2008 to December 2010, 41 patients with acute organophosphate poisoning were randomly divided into two groups according to the order of treatment. Twenty patients in the penehyclidine group were treated with penehyclidine hydrochloride and chlordecad, and 21 patients in the atropine group Atropine + chlorpromazine treatment. The efficacy of two groups of patients were analyzed. Results The length of disappearance of clinical symptoms (1.80 ± 1.12 vs 3.12 ± 1.15 d), length of hospital stay (9.20 ± 1.05) vs (12.34 ± 3.60) d, incidence of rebound (10.00% vs38.10%) were significantly lower than atropine group (all P <0.05). One patient died in the long tonic group and two patients died in the atropine group. Conclusions Changtunning is superior to atropine in the treatment of acute organophosphate poisoning with short course, less side effects, high cure rate and low case fatality rate.