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目的:探讨血清半胱氨酸蛋白酶抑制剂C(cyc)、尿微量白蛋白(mAlb)和视黄醇结合蛋白(RBP)测定在糖尿病肾损害的诊断价值。方法:测定200例II型糖尿病患者cyc、mAlb、RBP的含量,在OLYMPUS-640生化分析仪上,采用乳胶颗粒增强免疫比浊法测定血清Cyc、mAlb、RBP免疫透射比浊法,血清Cr、BUN、UA分别采用酶法。结果:糖尿病患者的常规尿检及常规肾功能检测与正常对照组比较无统计学意义(P>0.05),糖尿病患者cyc、RBP、mAlb均明显高于正常对照组及正常蛋白尿组(P<0.01)。结论:Cyc、RBP、mAlb均可做为糖尿病早期肾损害的灵敏指标,三者联合检测的诊断意义更大。
Objective: To investigate the diagnostic value of serum cystatin C, mAlb and retinol binding protein (RBP) in the diagnosis of diabetic nephropathy. Methods: The contents of cyc, mAlb and RBP in 200 type II diabetic patients were measured. On the OLYMPUS-640 biochemical analyzer, serum Cyc, mAlb, RBP immunoturbidimetric method, serum Cr, BUN, UA were used enzymatic method. Results: The routine urinalysis and routine renal function tests in diabetic patients were not statistically significant (P> 0.05). The levels of cyc, RBP and mAlb in diabetic patients were significantly higher than those in normal control group and normal proteinuria group (P <0.01) ). Conclusion: Cyc, RBP and mAlb can all be used as sensitive indicators of early diabetic nephropathy. The diagnostic value of combined detection of the three is more significant.