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人体免疫系统是抵御病原菌侵犯、防止肿瘤发生最重要的保卫系统。针对免疫系统中T/B淋巴细胞的免疫组库研究,找出肿瘤与TCR或BCR之间的关系,发现肿瘤特异性标志物,从而推动肿瘤特异性诊断、治疗及预后评估等的发展,特别是在肿瘤免疫组库研究基础上衍生出的癌症疫苗,可以在患者体内实现诱导定向肿瘤免疫反应,为肿瘤患者的治疗带来新希望。现从肿瘤免疫组库、癌症疫苗的研究进展等方面来阐述。
The human immune system is to defend against the invasion of pathogens, the most important defense system against tumorigenesis. To investigate the relationship between tumor and TCR or BCR in immune response to T / B lymphocytes in immune system, and to find tumor-specific markers to promote the development of tumor-specific diagnosis, treatment and prognosis evaluation. Is a cancer vaccine derived from the study of tumor immunity group library, which can induce the targeted tumor immune response in patients and bring new hope for the treatment of cancer patients. Now from the tumor immune bank, cancer vaccine research progress and other aspects to elaborate.