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目的： 研究肝细胞癌（ hepatocellular carcinoma, HCC）及癌旁组织 p21蛋白表达的意义。方法：应用免疫组化方法结合计算机图像分析技术测定 47例肝癌手术标本 p21蛋白的表达水平，并与临床病理学指标进行对比。 结果：癌旁组织 p21蛋白表达阳性率及表达水平均高于癌组织（ P<0.01),癌旁组织 p21蛋白表达水平在侵袭转移性HCC高于非侵袭无转移性HCC(P<0.01).并且癌旁组织P21蛋白表达水平高于癌组织的HCC,其侵袭转移等指标亦高于癌旁组织P21蛋白表达水平低于癌组织的病例(P<0.01).结论:肝癌旁组织P21蛋白的表达在评估其侵袭转移潜能方面可能是一个较癌组织本身更为有用的指标。
Objective: To study the significance of p21 protein expression in hepatocellular carcinoma (HCC) and adjacent tissues. Methods: The expression of p21 protein in 47 surgical specimens of hepatocellular carcinoma was determined by immunohistochemical method combined with computer image analysis technique, and compared with the clinical pathological indicators. RESULTS: The positive expression rate and expression level of p21 protein in adjacent tissues were higher than those in cancer tissue (P<0.01). The expression of p21 protein in adjacent tissues was higher in invasive and metastatic HCC than non-invasive and non-metastatic HCC (P<0.01). Furthermore, the expression of P21 protein in adjacent tissues was higher than that in cancer tissues, and the invasion and metastasis were also higher than those in adjacent tissues (P<0.01). Conclusions: The P21 protein in the tissues adjacent to liver cancer Expression may be a more useful indicator than cancer tissue itself in assessing its potential for invasion and metastasis.