用放射免疫方法测定食管癌病人放疗前后血清中表皮生长因子（Ｅｐｉｄｅｒｍ ａｌｇｒｏｗ ｔｈ ｆａｃｔｏｒ， ＥＧＦ）和肿瘤坏死因子（Ｔｕｍ ｏｒ ｎｅｃｒｏｓｉｓ ｆａｃｔｏｒ，ＴＮＦ）的含量变化，结果发现放疗后病人血清中ＥＧＦ及ＴＮＦ含量较放疗前显著降低，且下降幅度与疗效呈正相关。提示ＥＧＦ、ＴＮＦ在食管癌的发生发展中起重要作用，并可做为判断疗效的指标 Radioimmunoassay was used to determine the changes of serum epidermal growth factor (EGF) and tumour necrosis factor (TNF) levels in patients with esophageal cancer before and after radiotherapy. The TNF content was significantly lower than before radiotherapy, and the decrease was positively correlated with the efficacy. It is suggested that EGF and TNF play an important role in the occurrence and development of esophageal cancer, and can be used as an indicator of efficacy.