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本文简要综述了近年来通过抗体缺陷病人和抗体缺陷动物模型研究抗体抗病毒作用的研究进展,以及抗体控制病毒感染作用的一些新认识。抗体缺陷病人的感染原分析显示抗体在控制病毒感染性疾病中发挥重要作用,抗体缺陷动物模型实验进一步证实IgM型天然抗体能控制病毒在体内的播散,并促进特异性免疫应答的产生;获得性抗体在病毒初次感染的急性期与细胞免疫协同作用控制病毒的感染,而对同一病毒的再攻击,抗体能单独发挥作用,阻止病毒再感染疾病的发生。
This review summarizes recent research progress on antibody antiviral activity in antibody-deficient patients and antibody-deficient animal models, as well as some new insights into the role of antibodies in controlling viral infections. Antibody-deficient patients with infectious origin analysis showed that the antibodies play an important role in the control of viral infectious diseases. Antibody-deficient animal model experiments further confirmed that IgM-type natural antibodies can control the spread of the virus in vivo and promote the production of specific immune responses; Antibodies act synergistically with cellular immunity in the acute phase of virus primary infection to control the virus’s infection, whereas antibodies that re-attack the same virus alone can prevent the virus from re-infecting the disease.