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已有文献报告丁酰心安(Bufuralol)1’一羟化反应,去甲替林(Nortiptyline)-E-羟化反应和异喹胍(Debrisoguine)4-泾化反应均受同一酶系催化。该酶系统在人体表现出基因控制的遗传性多态性。本文用高效液相——萤光检测法,体外测定了去甲替林对人和大鼠肝细胞微粒体不同光学异体1’-羟化酶活体的影响。去甲替林50％抑制人
It has been reported that Bufuralol 1’-hydroxylation, Nortiptyline-E-hydroxylation and Debrisoguine-4-janation are all catalyzed by the same enzyme system. The enzyme system shows genetic controlled genetic polymorphism in the human body. In this study, the effect of nortriptyline on different optical isoforms of 1’-hydroxylase in human and rat hepatocyte microsomes was determined by HPLC-fluorescence assay. 50% of nortriptyline inhibits human