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BACKGROUND: Choledocholith is prevalent in some Asi- an countries and may lead to liver fibrosis and portal vein hypertension. Biliary drainage is an effective treatment for choledocholith. The aim of this study was to assess the im- pact of biliary drainage on liver fibrosis due to choledocho- lith. METHODS: Eight patients with liver fibrosis caused by choledocholith were followed up by biochemical tests (as- partate aminotransferase, alanine aminotransferase) and liver biopsy before and after biliary drainage, respectively. The severity of the fibrosis was scored on a scale from 0 to 3 (0: denoting none; 1: portal and periportal fibrosis; 2: the presence of numerous fiber septa; and 3: cirrhosis). The results were analyzed statistically. RESULTS: The severity scores of liver fibrosis in the 8 pa- tients were 2,1; 2,1; 1,0; 1,1; 2,1; 1,1; 2,1; 1,0 before and after biliary drainage, respectively. The results showed that the average severity of liver fibrosis decreased signifi- cantly after biliary drainage (n =8, t =4.573 P =0.003). CONCLUSION: Liver fibrosis due to choledocholith may regress after biliary drainage.
BACKGROUND: Choledocholith is prevalent in some Asi- an countries and may lead to liver fibrosis and portal vein hypertension. The aim of this study was to assess the im- pact of biliary drainage on liver fibrosis due to choledocho- lith. METHODS: Eight patients with liver fibrosis caused by choledocholith were followed up by biochemical tests (as-partate aminotransferase, alanine aminotransferase) and liver biopsy before and after biliary drainage, respectively. The severity of the fibrosis was scored on a scale: from 0 to 3 (0: denoting none; 1: portal and periportal fibrosis; 2: the presence of numerous fiber septa; and 3: cirrhosis). The results were statistically significant. RESULTS: The severity scores of liver fibrosis in the 8 pa tients were 2,1; 2,1; 1,0; 1,1; 2,1; 1,1; 2,1; 1,0 before and after biliary drainage, respectively. The results showed that the average severity of liver fibrosis decreased signifi- cantly a fter biliary drainage (n = 8, t = 4.573 P = 0.003). CONCLUSION: Liver fibrosis due to choledocholith may regress after biliary drainage.