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目的了解肝硬化患者不同CTP分级及出现不同并发症时与小肠细菌过度生长(SIBO)的关系。方法对68例肝硬化患者,均行葡萄糖氢呼气试验(GHBT)检测SIBO情况,按不同CTP分级、不同并发症分组统计,并设立健康对照组,对检测结果作对比分析。结果 (1)肝硬化患者SIBO与健康对照组比较差异有统计学意义(P<0.05);(2)CTP级A级、B级、C级患者SIBO阳性率及氢呼气浓度平均值呈渐进性增高,A级、B级与C级相比组间差异有统计学意义(P<0.05);(3)不同并发症患者SIBO阳性率及氢呼气浓度不一,其中无并发症患者与上消化道出血患者、肝性脑病患者、自发性腹膜炎患者及多种并发症患者相比差异均有统计学意义(P<0.05)。结论肝硬化患者往往合并有SIBO,其与CTP分级相关,而且与肝硬化出现的不同并发症密切相关。
Objective To understand the relationship between different CTP grade and different complications of cirrhosis patients and intestinal bacterial overgrowth (SIBO). Methods Sixty-eight patients with cirrhosis were examined with glucose-hydrogen breath test (GHBT) for detecting SIBO. The patients were divided into different CTP grades and different complications, and healthy control group was set up to compare the results. Results (1) The SIBO in patients with cirrhosis was significantly different from that in healthy controls (P <0.05). (2) The positive rates of SIBO and hydrogen expiration in CTP patients with grade A, B, (P <0.05). (3) The positive rate of SIBO and the concentration of hydrogen expiration in patients with different complications were different. Among them, the patients with no complications and Patients with upper gastrointestinal bleeding, patients with hepatic encephalopathy, patients with spontaneous peritonitis and a variety of complications were significantly different (P <0.05). Conclusions Patients with cirrhosis often have SIBO associated with CTP grading and are closely related to the different complications of cirrhosis.