目的了解江苏省盐城市健康儿童b型流行性感冒嗜血杆菌(Hib)多糖抗体水平。方法采用酶联免疫吸附试验检测543名0～14岁儿童Hib-IgG抗体。结果盐城市14岁以下儿童血清抗Hib-多肽络胺化物标准抗体(PRP)总阳性率为47.33%,其中男性为46.20%,女性为48.75%,男女性别间差异无统计学意义。不同年龄抗体水平发生不同,新生儿脐带血抗体水平最高,为72%,而后抗体水平逐步下降;12月龄最低为25.49%,1岁以后随年龄增长而逐步增高;10～14岁年龄组达71.64%。结论盐城市儿童具有一定的抗Hib多糖抗体水平,但3～12月龄儿童抗体水平最低,为Hib感染的高危人群。 Objective To understand the antibody level of Hib polysaccharide in healthy children in Yancheng, Jiangsu Province. Methods Enzyme linked immunosorbent assay was used to detect Hib-IgG antibodies in 543 children aged 0-14 years. Results The positive rate of serum anti-Hib-polypeptide complexing antibody (PRP) in children under 14 years of age was 47.33% in Yancheng City, including 46.20% for males and 48.75% for females. There was no significant difference between male and female. Antibody levels at different ages have different neonatal umbilical cord blood antibodies, the highest level of 72%, and then gradually reduced antibody levels; the lowest at 12 months was 25.49%, after 1 year of age and gradually increased with age; 10 to 14 age group 71.64%. Conclusion Children in Yancheng City have some anti-Hib polysaccharide antibody levels, but the antibody levels are the lowest in children aged 3 ~ 12 months and are at high risk for Hib infection.