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获得性免疫缺陷综合征(acquired immunodeficiency syndrome,AIDS)主要是由HIV-1感染人体免疫细胞所造成,而介导HIV-1病毒进入机体细胞的主要辅助受体为趋化因子受体CCR5[chemokine(C-C motif)receptor 5],目前以CCR5为研究靶点阻断HIV-1感染的方法在医学和生物学领域备受关注,主要包括CCR5拮抗剂、RNA干扰(RNA interference,RNAi)、锌指核酸酶(zinc-finger nuclease,ZFN)和转录激活因子样效应物核酸酶(transcription activator-like effectors nuclease,TALEN)技术。趋化因子受体CCR5阻断HIV-1感染方法的相关研究进展有必要进行综述。
Acquired immunodeficiency syndrome (AIDS) is mainly caused by the HIV-1 infection of human immune cells, and the main auxiliary receptor that mediates the entry of HIV-1 into the body cells is the chemokine receptor CCR5 [chemokine (CC motif) receptor 5]. At present, methods of blocking HIV-1 infection targeting CCR5 are of great interest in the fields of medicine and biology and mainly include CCR5 antagonists, RNA interference (RNAi), zinc fingers Zinc-finger nuclease (ZFN) and transcription activator-like effectors nuclease (TALEN) technology. The research progress of chemokine receptor CCR5 in blocking HIV-1 infection needs to be reviewed.