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目的肿柄菊乙酸乙酯部位化学成分的提取、分离和结构鉴定。方法肿柄菊地上部分80%的乙醇渗漉提取,通过萃取、硅胶柱层析、凝胶柱层析、MCI柱层析等方法进行成分分离,应用质谱、核磁等方法进行结构鉴定。结果从乙酸乙酯部位得到10个化合物,鉴定为香草醛(1)、麦角甾醇(2)、过氧化麦角甾醇(3)、3-甲氧基-4-羟基肉桂醛(4)、对羟基苯甲醛(5)、异东莨菪内酯(6)、5-羟甲基糠醛(7)、尼泊尔黄酮(8)、二十二烷酸单甘油酯(9)和13-羟基泽兰烯(10)。结论香草醛、麦角甾醇、过氧化麦角甾醇、3-甲氧基-4-羟基肉桂醛、对羟基苯甲醛、异东莨菪内酯、5-羟甲基糠醛、二十二烷酸单甘油酯和13-羟基泽兰烯均为首次从肿柄菊中分离得到。
OBJECTIVE To extract, isolate and identify the chemical constituents of Ethyl actetate ethyl acetate. Methods The upper part of Eupatorium adenophorum with 80% ethanol percolation extraction, extraction, silica gel column chromatography, gel column chromatography, MCI column chromatography and other components of the separation method, the application of mass spectrometry, nuclear magnetic resonance and other structural identification. As a result, 10 compounds were obtained from the ethyl acetate fraction and identified as vanillin (1), ergosterol (2), ergosterol peroxide (3), 3-methoxy-4-hydroxycinnamaldehyde (6), 5-hydroxymethylfurfural (7), Nepalese flavonoid (8), behenic acid monoglyceride (9) and 13- 10). Conclusions Vanillin, ergosterol, ergosterol peroxide, 3-methoxy-4-hydroxycinnamaldehyde, p-hydroxybenzaldehyde, isoedenolide, 5-hydroxymethylfurfural, behenic monoglyceride And 13-hydroxy-Zelandin were isolated from Erythroculter for the first time.