论文部分内容阅读
背景:甲状腺功能亢进症及其导致的骨质疏松逐年增多。研究此时患者体内生长激素的变化情况,以便进一步认识其病理生理变化的机制。目的:了解甲亢合并骨质疏松患者血清生长激素水平的变化,以及甲状腺素水平、年龄、病程等相关因素对骨量丢失的影响。设计:病例分析。单位:河北省保定市第一中心医院内分泌科。对象:本研究在河北省保定市第一中心医院内分泌科完成。选择1999-10/2000-09本院门诊及住院的初诊甲亢患者146例。按骨密度(bonemineraldensity,BMD)分为BMD正常组44例,骨量减少组78例和骨质疏松组24例。方法:空腹采集肘静脉血,以同一批试剂测定生长激素(GH)、钙(Ca)、碱性磷酸酶(ALP)、甲状腺素T3(T3)及甲状腺素T4(T4)浓度。以直线相关分析法检验上述各变量间的相关性,并比较3组之间的差异。主要观察指标:①3组患者BMD测定结果的比较。②3组患者静脉血GH,Ca,ALP,T3,T4浓度的比较。结果:GH、ALP与BMD之间有非常显著负相关(r=-0.456,P<0.001)。GH与年龄,病程,T3,T4等指标之间无显著相关性(r=0.005～0.119,P>0.10)。Neck,Ward’s,G.T.3部位的BMD与T3、T4及病程之间呈显著负相关犤r=(-0.212)～(-0.165),P<0.05犦,而L2-4的BMD与上述3指标无显著相关性(r=0.010～0.115,P>0.10)。结论:甲亢合并骨质疏松患者?
Background: Hyperthyroidism and osteoporosis caused by it are increasing year by year. Study of patients with growth hormone in vivo changes in order to further understand its pathophysiological changes in the mechanism. Objective: To investigate the changes of serum growth hormone (Hg) in patients with hyperthyroidism complicated with osteoporosis and the effects of related factors such as thyroid hormone level, age, course of disease on bone loss. Design: Case Analysis. Unit: Department of Endocrinology, First Central Hospital, Baoding, Hebei Province. PARTICIPANTS: This study was completed in the Department of Endocrinology, the First Central Hospital of Baoding, Hebei Province. Select 1999-10 / 2000-09 hospital outpatient and inpatient newly diagnosed patients with hyperthyroidism in 146 cases. According to the bone mineral density (bonemineraldensity, BMD) divided into normal BMD group 44 cases, 78 cases of osteopenia group and 24 cases of osteoporosis group. Methods: The elbow venous blood was collected on an empty stomach. The concentrations of GH, Ca, ALP, T3 and T4 were determined with the same reagent. Linear correlation analysis was used to test the correlation between the above variables, and to compare the differences between the three groups. MAIN OUTCOME MEASURES: ① Comparison of BMD measurement results in 3 groups. ② Group 3 patients with venous blood GH, Ca, ALP, T3, T4 concentration comparison. Results: There was a significant negative correlation between GH, ALP and BMD (r = -0.456, P <0.001). GH and age, duration, T3, T4 and other indicators no significant correlation (r = 0.005 ~ 0.119, P> 0.10). There was a significant negative correlation between BMD and T3, T4 and course of disease in Neck, Ward’s and GT3 (r = -0.212 ~ -0.165, P <0.05), while BMD in L2-4 and none of the above three indicators Significant correlation (r = 0.010 ~ 0.115, P> 0.10). Conclusion: hyperthyroidism patients with osteoporosis?