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目的 研究四抗感冒口服液 (CCD)的镇痛作用。方法 应用热诱发小鼠疼痛反应模型和冰醋酸诱导小鼠扭体反应模型观察CCD对疼痛的抑制作用。结果 CCD 5 0 g/kg和 10 0 g/kg可明显延长小鼠热痛反应潜伏期 (P <0 0 5 ,P <0 0 1) ,提高小鼠的痛阈值 ,且维持时间较阿司匹林长 ;CCD 10 0 g/kg与 2 0 0g/kg对小鼠扭体反应次数有明显抑制作用 (P <0 0 1)。 结论 CCD具有镇痛作用 ,且作用维持时间较长。
Objective To study the analgesic effect of Si Kang Kuang Oral Liquid (CCD). Methods The pain-inhibitory effect of CCD was observed in a thermal-induced mouse pain response model and a acetic acid-induced mouse writhing response model. Results CCD 50 g/kg and 100 g/kg significantly prolonged the latency of thermal pain response in mice (P < 0.05, P <0.01), increased the pain threshold of mice, and maintained longer than aspirin. The number of writhing responses in mice was significantly inhibited by CCD 100 g/kg and 200 g/kg (P < 0 01). Conclusion CCD has analgesic effect, and the role of maintaining a longer time.