以具有核壳结构的Au@SiO2纳米颗粒为基底,建立了一种以表面增强拉曼(SERS)原位、快速检测食品中非法添加剂酸性橙Ⅱ的新方法.研究了活性硅加入量对所形成的Au@SiO2纳米颗粒的SERS活性的影响,制备了具有最佳SERS活性的Au@SiO2,并以此为SERS基底建立了酸性橙Ⅱ的分析方法,可实现0.17 mg/L酸性橙Ⅱ的SERS检测.将合成的Au@SiO2滴加到瓜子表面后,可以实现对瓜子表面酸性橙Ⅱ浓度为0.01 mg/g时的SERS检测,能够满足食品中酸性橙Ⅱ的测定要求,有望用于瓜子及其它可能被非法添加该物质的食品的现场、快速检测. Based on Au @ SiO2 nanoparticles with core-shell structure, a new method for the rapid determination of acidic orange II in food by surface-enhanced Raman (SERS) in situ was developed. Au @ SiO2 with the best SERS activity was prepared by using the SERS activity of the formed Au @ SiO2 nanoparticle. Based on this, an analytical method of acidic orange Ⅱ for SERS substrate was established, which could achieve the acid orange Ⅱ of 0.17 mg / L SERS.The addition of Au @ SiO2 to the surface of melon seeds could achieve SERS detection when the concentration of Acid Orange II on the surface of melon seeds was 0.01 mg / g, which could meet the determination requirements of Acid Orange Ⅱ in food and was expected to be used in melon seeds And other foods that may have been illegally added to the scene, rapid testing.