抗癌药醋酸两面针在临床早有应用。近来发现醋酸两面针在碱性溶液中会吸收空气中的氧,变成氧化两面针,报道了氧化两面针的晶体结构,并阐明氧化两面针在酸性溶液中不能形成醋酸两面针。但至今未见国内外用高效液相色谱方法来研究醋酸两面针的报道。我们用高效液相色谱详细研究了在温和条件下醋酸两面针变成氧化两面针的情况,对阐明两面针的抗癌作用机理具有一定意义。 Acetate needle anticancer has long been in clinical application. Recently, it was found that acetic acid pinned needle in alkaline solution will absorb the oxygen in the air into two-sided oxidation needle, reported the crystal structure of two-sided needle oxidation and clarify the oxidation of two-way needle in acidic solution can not form acetate needle. But so far no high-performance liquid chromatography at home and abroad to study the acetic acid needle on both sides of the report. We used HPLC to study in detail the condition that the two-sided needle of acetic acid turns into the oxidized two-sided needle under mild conditions, which is of significance to clarify the anticancer mechanism of the two-sided needle.