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目的观察替硝唑联合西帕依固龈液治疗单纯牙周炎的疗效及对血清C反应蛋白(C-reactionprotein,CRP)、干扰素α(interferon-α,IFN-α)及白细胞介素6-(interleukelin-6,IL-6)水平的影响。方法将2014年3月—2016年10月收治的115例单纯性牙周炎患者作为研究对象,随机分为对照组(n=50)和观察组(n=65)。对照组采用替硝唑治疗,观察组在对照组的基础上给予西帕依固龈液治疗,检测血清CRP、IFN-α及IL-6水平,观察记录菌斑指数(plaque index,PI)、探诊出血指数(sulcus bleeding index,SBI)、探诊深度(probing depth,PD)、附着丧失(attachment loss,AL),并比较临床总有效率。计量资料组间比较采用t检验,组内比较采用配对t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果治疗3周后,两组患者PI、SBI、PD、AL水平分别为(1.87±0.49)、(1.85±0.80)分、(3.13±0.38)、(2.59±0.46)mm,(2.44±0.55)、(3.53±0.58)分、(3.89±0.34)、(2.94±0.49)mm,均较治疗前的(2.68±0.61)、(3.95±0.79)分、(4.46±0.57)、(3.25±0.63)mm,(2.71±0.63)、(3.97±0.80)分、(4.47±0.56)、(3.19±0.58)mm有所改善,差异均有统计学意义(均P<0.05)。治疗3周后,观察组患者总有效率(93.85%)明显优于对照组(70.00%),差异有统计学意义(P<0.05)。治疗后,观察组与对照组患者CRP、IFN-α及IL-6水平分别为(1.36±0.89)mg/L、(12.68±4.99)、(16.14±4.31)μg/L、(2.67±0.93)mg/L、(26.32±6.01)、(2.94±0.49)μg/L,均较治疗前的(4.38±1.24)mg/L、(35.73±10.27)、(41.39±9.75)μg/L、(4.35±1.21)mg/L、(3.97±0.80)、(41.41±9.77)μg/L显著降低,差异均有统计学意义(均P<0.05)。治疗后,观察组各指标均优于对照组,差异均有统计学意义(均P<0.05)。结论替硝唑联合西帕依固龈液治疗单纯牙周炎,临床疗效显著,并能显著降低血清CRP、IFN-α及IL-6水平,改善牙周炎症状态。
Objective To observe the curative effect of tinidazole combined with cipaprazine on human periodontitis and its effect on the expression of C-reactive protein (C-reactive protein, interferon-α, Interleukin-6 and Interleukin- - (interleukelin-6, IL-6) levels. Methods One hundred and fifteen patients with simple periodontitis admitted from March 2014 to October 2016 were randomly divided into control group (n = 50) and observation group (n = 65). The control group was treated with tinidazole. The observation group was given ciprofloxacin on the basis of the control group. Serum levels of CRP, IFN-α and IL-6 were measured. The plaque index (PI) The sulcus bleeding index (SBI), probing depth (PD), attachment loss (AL) were compared, and the total clinical efficiency was compared. Measurement data were compared between groups using t test, the group was compared using paired t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results After three weeks of treatment, the levels of PI, SBI, PD and AL were (1.87 ± 0.49), (1.85 ± 0.80), (3.13 ± 0.38), (2.59 ± 0.46) mm and (2.44 ± 0.55) , (3.53 ± 0.58), (3.89 ± 0.34) and (2.94 ± 0.49) mm respectively, which were significantly higher than those before treatment (2.68 ± 0.61), (3.95 ± 0.79), (4.46 ± 0.57) and (3.25 ± 0.63) mm, 2.71 ± 0.63, 3.97 ± 0.80, 4.47 ± 0.56 and 3.19 ± 0.58 mm respectively (all P <0.05). After 3 weeks of treatment, the total effective rate (93.85%) in the observation group was significantly better than that in the control group (70.00%), the difference was statistically significant (P <0.05). After treatment, the levels of CRP, IFN-α and IL-6 in the observation group and the control group were (1.36 ± 0.89) mg / L, (12.68 ± 4.99), (16.14 ± 4.31) μg / L and (2.67 ± 0.93) (4.38 ± 1.24) mg / L, (35.73 ± 10.27), (41.39 ± 9.75) μg / L, (4.35 ± 0.49) μg / L and (26.32 ± 6.01) ± 1.21) mg / L, (3.97 ± 0.80) and (41.41 ± 9.77) μg / L respectively, with statistical significance (all P <0.05). After treatment, the indicators of the observation group were better than the control group, the differences were statistically significant (P <0.05). Conclusion Tinidazole combined with ciprofet in the treatment of simple periodontitis has significant curative effect and can significantly reduce serum levels of CRP, IFN-α and IL-6 and improve periodontal inflammation status.