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目的:探讨准分子激光原位角膜磨镶术(laser in situ keratomileusis LASIK)术后干眼症的相关因素。方法:观察816例1 632眼行LASIK治疗的近视患者术后干眼症状,其中术中将150例患者的左右眼角膜瓣蒂部随机置于角膜上方或鼻侧,分别于术前、术后1周、1个月、3个月、6个月行干眼问卷调查、泪液分泌量检查、角膜荧光染色、泪膜破裂时间检查。结果:术后1周、1个月、3个月干眼症状明显,与术前相比差异有显著意义;术后1周、1个月、3个月泪液分泌减少与术前相比差异有显著意义;术后1周、1个月角膜着色眼数明显增加,与术前相比差异有显著意义;术后1周、1个月BUT缩短,与术前相比差异有显著意义。角膜瓣蒂部位于上方组与位于鼻侧组之间术后干眼症状、泪膜破裂时间、角膜荧光染色、泪液分泌量无显著差异。结论:LASIK术后1周、1个月干眼患者较术前增加,术后6个月干眼缓解。角膜瓣蒂部位置对干眼症无显著影响。
Objective: To investigate the related factors of dry eye after laser in situ keratomileusis (LASIK). Methods: Eighty-six eyes of 1632 eyes underwent LASIK for treatment of myopia. The left and right corneal pedicle of 150 patients were randomly placed on the cornea or nasal cavity, 1 week, 1 month, 3 months, 6 months dry eye questionnaire survey, tear secretion examination, corneal fluorescence staining, tear film rupture time examination. Results: After 1 week, 1 month, 3 months, the symptom of dry eye was obvious, which had significant difference compared with that before operation; The tear secretion decreased at 1 week, 1 month and 3 months after operation compared with that before operation There was a significant difference between the two groups. The number of corneal stained eyes increased significantly at 1 week and 1 month after operation, which was significantly different from that before operation. The BUT shortened at 1 week and 1 month after operation was significantly different from that before operation. Corneal pedicle pedicle is located between the upper group and the nasal group postoperative dry eye symptoms, tear film rupture time, corneal fluorescence staining, tear secretion was no significant difference. Conclusion: One week after LASIK, one month’s dry eye patients increased compared with that before operation, and the dry eye was relieved 6 months after LASIK. Corneal pedicle pedicle position had no significant effect on dry eye.