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利用免疫组化技术对１１１例原发性人口腔粘膜鳞癌的ｐ５３蛋白表达进行了研究，并探讨了ｐ５３蛋白表达同口腔鳞癌的临床、病理和预后间的关系。研究结果表明：（１）口腔鳞癌有较高的ｐ５３蛋白阳性表达率（６９．４％），ｐ５３蛋白阳性表达可作为口腔癌癌变发生的一个标志。（２）ｐ５３蛋白表达情况同口腔癌的发生部位、性别、年龄、肿瘤大小、病理分级及淋巴结转移情况均无直接关系，同临床分期的关系也不十分明确。（３）ｐ５３蛋白染色阳性反应越强的口腔癌患者，其３年、５年生存率越差。（４）单因素ＣＯＸ风险比例模型分析证实ｐ５３蛋白阳性反应强弱并非影响口腔癌患者预后的主要因素，多因素ＣＯＸ模型分析未能建立有效的生存函数或危险率函数，说明所选指标及ｐ５３染色均不是影响口腔癌预后的非常有效的风险指标。
The expression of p53 protein in 111 cases of primary human oral squamous cell carcinoma was studied by immunohistochemistry and the relationship between p53 protein expression and clinical, pathological and prognosis of oral squamous cell carcinoma was discussed. The results showed that: (1) The positive expression rate of p53 protein in oral squamous cell carcinoma (69.4%) was high, and the positive expression of p53 protein could be used as a marker of carcinogenesis in oral cancer. (2) The expression of p53 protein is not directly related to the occurrence site, sex, age, tumor size, pathological grade and lymph node metastasis of oral cancer, and the relationship between p53 protein expression and clinical stage is not clear. (3) The positive response of p53 protein staining in oral cancer patients, the 3-year, 5-year survival rate worse. (4) The single factor COX risk proportional model analysis confirmed that the positive rate of p53 protein positive reaction is not the main factor affecting the prognosis of oral cancer patients. Multivariate COX model analysis failed to establish an effective survival function or risk function, indicating that the selected indicators and p53 Staining is not a very effective risk indicator for the prognosis of oral cancer.