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目的探讨血清降钙素原在急性细菌性脑膜炎及病毒性脑炎的诊断价值。方法应用免疫荧光法对52例中枢神经系统感染患儿的血清降钙素原水平进行测定,并比较C反应蛋白、外周血白细胞计数、脑脊液白细胞数、蛋白含量对感染病因辅助诊断的价值。结果 24例急性细菌性脑膜炎患儿血清降钙素原水平明显升高,28例病毒性脑炎的血清降钙素原水平仅轻度升高(P<0.05)。而血清C反应蛋白、脑脊液白细胞数及蛋白含量在急性细菌性脑膜炎及病毒性脑炎中有重叠。结论血清降钙素原对鉴别小儿急性细菌性脑膜炎及病毒性脑炎有重要价值。
Objective To investigate the diagnostic value of serum procalcitonin in acute bacterial meningitis and viral encephalitis. Methods Serum procalcitonin levels in 52 children with central nervous system infection were measured by immunofluorescence method. The value of C-reactive protein, peripheral blood leukocyte count, leukocyte count and protein content of cerebrospinal fluid in the diagnosis of infectious etiology were compared. Results Serum procalcitonin levels in 24 patients with acute bacterial meningitis were significantly higher than those in 28 viral encephalitis patients (P <0.05). The serum C-reactive protein, cerebrospinal fluid leukocyte and protein content in acute bacterial meningitis and viral encephalitis in overlap. Conclusion Serum procalcitonin has important value in differentiating acute bacterial meningitis and viral encephalitis in children.