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目的 :探讨脑缺血患者血清可溶性细胞间粘附分子 1(sICAM 1)和可溶性血管细胞间粘附分子 1(sVCAM 1)水平的动态变化规律及其意义。方法 :应用ELISA法分别检测脑缺血后第 1、2、5天患者血清中sICAM 1、sVCAM 1水平 ,同时测定第 2天血糖水平。结果 :发病后 2 4小时内患者血清中sICAM 1、sVCAM 1水平即开始升高 ,分别为 2 6 6 .2 8± 6 2 .16ng/ml、6 87.19±356 .76ng/ml;第 2天明显升高 2 85.77± 6 8.4 3ng/ml、990 .79± 36 8.36ng/ml;第 5天又有所下降 ,分别为 2 6 3.6 0± 87.82ng/ml、977.70± 384 .16ng/ml,但仍高于对照组。发病后第 2天血糖水平与sICAM 1水平升高呈线性正相关。结论 :脑缺血患者血清sICAM 1、sVCAM 1水平均升高 ,表明ICAM 1和VCAM 1可能参与了脑缺血损伤过程
Objective: To investigate the dynamic changes of serum soluble intercellular adhesion molecule 1 (sICAM 1) and soluble vascular cell adhesion molecule 1 (sVCAM 1) in patients with cerebral ischemia and its significance. Methods: Serum levels of sICAM 1 and sVCAM 1 were detected by enzyme-linked immunosorbent assay (ELISA) on the 1st, 2nd and 5th day after cerebral ischemia, and the blood glucose level on the second day was measured. Results: Serum levels of sICAM 1 and sVCAM 1 began to increase within 24 hours after onset, respectively, which were respectively 26.62.8 ± 6.22.16ng / ml and 6 87.19 ± 356.76ng / ml; on the second day Significantly increased 2 85.77 ± 6 8.4 3ng / ml, 990.79 ± 36 8.36ng / ml; on the 5th day, it decreased a little, which were 2636 ± 87.82ng / ml, 977.70 ± 384.16ng / ml, But still higher than the control group. On the second day after the onset of blood glucose levels and sICAM 1 levels increased linearly and positively. Conclusion: The levels of serum sICAM 1 and sVCAM 1 are increased in patients with cerebral ischemia, indicating that ICAM 1 and VCAM 1 may be involved in the process of cerebral ischemic injury