溶组织内阿米巴病在致死性寄生虫病中 仅次于疟疾和血吸虫病而名列第三,每年至少有4万人因此病而死亡。阿米巴的红细胞吞噬作用历来被实验室用作区分其致病性的主要标准;而阿米巴虫株的毒力又与其红细胞吞噬率有相关关系。因其吞噬作用相似于巨噬细胞,作者研究了介导巨噬细胞“自杀”的脂质体包裹药物对侵袭性阿米巴(E.i.)的作用。 Tissue Entamoeba histopatum is third only to malaria and schistosomiasis in lethal parasitic diseases, with at least 40,000 people each year dying of the disease. Phagocytosis of amebocytes has traditionally been used by laboratories as a major criterion for the distinction of its pathogenicity, whereas the virulence of amoeba strains correlates with its rate of erythrocyte phagocytosis. Because of its phagocytosis similar to macrophages, the authors investigated the effect of liposome-encapsulated drugs that “kill” macrophages on invasive amoebas (E.i.).