【摘 要】
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AIM: To investigate the expression of 1A6 gene in the lesionsduring the development of intestinal gastric carcinoma.METHODS: One hundred and thirty-six cases of
【机 构】
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Department of Pathology, Peking University school of Oncology, Beijing 100036, China“,”Laboratory of
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AIM: To investigate the expression of 1A6 gene in the lesionsduring the development of intestinal gastric carcinoma.METHODS: One hundred and thirty-six cases of intestinalmetaplasia (IM) from surgical resections and biopsy wereclassified by mucous staining. Expression of 1A6 in all caseswas detected using immunohistochemical S-P method.RESULTS: The positive rates of 1A6in normal and superficialgastritis (SG), severe atrophic gastritis (SAG), type Ⅰ, Ⅱ, ⅢIM, dysplasia (Dys) and intestinal gastric carcinoma (IGC)were 12.2 %, 16.7 %, 7.1%, 22.6 %, 47.8 %, 46.9 % and60.8 %, respectively. A significant difference among typeⅢ IM and SG, SAG, type I and Ⅱ IM was found (P＜0.01),the difference between type Ⅲ and Dys, IGC being notsignificant.CONCLUSION: As a new tumor-related gene, expression of1A6 may be an effective parameter to predict the malignanttransformation of precancerous lesion to gastric carcinoma.
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