目的观察护理干预对聚乙二醇干扰素α-2a治疗乙肝患者依从性的影响。方法按照随机抽取的方式将乙肝患者125例分为护理组63例和对照组62例。所有患者均给予常规护肝药物如维生素等进行治疗,并皮下注射聚乙二醇干扰素α-2a进行治疗,连续用药48周,且均不接受其他抗病毒药物治疗。护理组在此基础上加用护理干预,包括行为、饮食、药物治疗、认识、心理等方面。比较观察2组社会性功能、心理健康、机体疼痛、躯体功能等方面的生活质量评分及治疗的依从性。结果治疗后2组患者社会性功能、心理健康、躯体功能等方面的生活质量评分均提高,机体疼痛评分均降低,与治疗前比较差异均有统计学意义(P<0.05);且护理组患者各项评分变化幅度较大,2组间比较差异有统计学意义(P<0.05)。护理组患者治疗依从性优良率为90.5%高于对照组的61.3%,差异有统计学意义(P<0.05)。结论护理干预可明显提高聚乙二醇干扰素α-2a治疗乙肝的依从性,具有较大的临床推广意义。 Objective To observe the effect of nursing intervention on the adherence of pegylated interferon α-2a to hepatitis B patients. Methods 125 patients with hepatitis B were randomly divided into nursing group (63 cases) and control group (62 cases). All patients were given conventional liver protection drugs such as vitamins and other treatment, and subcutaneous injection of peginterferon alfa-2a treatment, continuous medication for 48 weeks, and are not receiving other antiviral drugs. Based on this, the nursing group added nursing intervention, including behavior, diet, medication, cognition and psychology. The social quality of life, mental health, body pain, body function and other aspects of quality of life scores and treatment compliance were observed. Results After treatment, the scores of social quality, mental health, physical function and other aspects of the quality of life of the two groups were improved, and the pain scores of the two groups were decreased after treatment, which were significantly different from those before treatment (P <0.05) The scores varied greatly, the difference between the two groups was statistically significant (P <0.05). The excellent and good treatment compliance rate was 90.5% in the nursing group and 61.3% in the control group, the difference was statistically significant (P <0.05). Conclusion Nursing intervention can significantly improve the compliance of pegylated interferon α-2a in treating hepatitis B, which has great clinical significance.