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目的:观察以羟基喜树碱(HPT)为主的化疗药经肝动脉灌注合并栓塞治疗中晚期原发性肝癌的疗效.方法:从1993年9月～1998年2月,采用HPT、吡柔比星、顺铂或5-氟脲嘧啶与碘化油联合经肝动脉灌注栓塞,治疗不能手术的中晚期肝癌41例.结果:41例患者共接受102次介入治疗.部分缓解21例,稳定16例,进展4例,总有效率51.2%.30例患者血清AFP≥200ug/L,经治疗后22例AFP明显下降或恢复正常.生存率6个月为87.2%,1年58.1%,2年19.0%.不良反应主要为骨髓抑制(Ⅰ度～Ⅲ度)和消化道反应(Ⅰ度～Ⅱ度).结论:肝动脉灌注以HPT为主的药物合并栓塞治疗中、晚期肝癌,疗效好,毒副反应小.
Objective: To observe the efficacy of hepatic arterial infusion and embolization with hydroxycamptothecin (HPT)-based chemotherapeutic drugs for the treatment of advanced primary liver cancer. Methods: From September 1993 to February 1998, HPT and piroufil were used. Orbital cisplatin or 5-fluorouracil and 5-fluorouracil combined with iodized oil via hepatic artery embolization for the treatment of 41 cases of inoperable advanced hepatocellular carcinoma. Results: 41 patients received a total of 102 interventional treatments. Partial remission in 21 cases, stable 16 cases, 4 cases progressed, and the total effective rate was 51.2%. 30 patients had serum AFP ≥200ug/L. After treatment, 22 cases of AFP decreased or returned to normal. The survival rate was 87.2% at 6 months and 58.1% at 1 year. The adverse reactions were mainly myelosuppression (I degree to III degree) and digestive tract reaction (I degree to II degree). Conclusion: Hepatic artery perfusion with HPT-based drugs combined with embolization for the treatment of middle and late stage liver cancer , The toxicity is small.