结节红斑和硬红斑在皮肤科里并不少见。这二种病均好发于春季,以女性患者为多见,临床表现相似,患部疼痛,肿胀,症状较重者有低烧、乏力,影响生产。尤其是硬红斑,病程比较长,破溃后不易收口,给病人很大痛苦。过去治疗结节红斑,常用皮质类固醇制剂或胎盘片。但长期用皮质类固醇制剂有副作用,停用后常易复发;而胎盘片由于药源限制,不易普遍使用。治疗硬红斑一般用抗结核疗法,但许多病人对链霉素有毒性反应。二年来我们用 Nodular erythema and hard erythema are not uncommon in dermatology. Both diseases are common in the spring, female patients are more common, similar clinical manifestations, the affected area pain, swelling, severe symptoms have low-grade fever, fatigue, affecting production. Especially the hard erythema, longer course, not easy to shut up after ulceration, to the patient a lot of pain. In the past treatment of erythema nodosum, commonly used corticosteroid preparations or placenta. But long-term use of corticosteroid preparations have side effects, often easy to relapse after discontinuation; and placental tablets due to drug restrictions, not easy to use. Hard erythema is generally treated with anti-TB therapy, but many patients have a toxic reaction to streptomycin. Two years we use