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目的探讨神经节苷酯治疗新生儿缺氧缺血性脑病(HIE)的疗效。方法选择2010年3月—2013年12月住院的62例HIE随机分为二组:治疗组32例,对照组30例,观察二组临床症状、体征消失时间,同时进行新生儿行为神经评分(NBNA),并作统计学处理。结果治疗组临床症状、体征明显改善,NBNA评分明显提高,与对照组比较,差异有统计学意义(P<0.01)。结论神经节苷酯具有神经保护作用,能促进神经功能的早期恢复,阻断继发性脑损伤的发病过程,提高治愈率,降低致残率。临床疗效显著,值得临床推广应用。
Objective To investigate the efficacy of ganglioside in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Methods Sixty-two HIE patients hospitalized from March 2010 to December 2013 were randomly divided into two groups: the treatment group (32 cases) and the control group (30 cases). The clinical symptoms and signs disappeared and the neonatal behavioral neurological score NBNA), and for statistical analysis. Results The clinical symptoms and signs of the treatment group were significantly improved, and the NBNA score was significantly increased. Compared with the control group, the difference was statistically significant (P <0.01). Conclusion Gangliosides have neuroprotective effect, which can promote the early recovery of nerve function, block the pathogenesis of secondary brain injury, improve the cure rate and reduce the morbidity. Significant clinical effect, it is worth clinical application.