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目的为了解新疆乌鲁木齐市维吾尔族人群中高尿酸血症组与正常组血尿酸、血脂及其肾功能生化指标的差异。方法采用病例对照研究方法,调查乌鲁木齐市某附属医院就诊的维吾尔族高尿酸血症患者986名,同期体检者1 353名,年龄平均为20~80岁,对两组人群进行问卷调查,体格检查和血生化检测,统计并分析维吾尔族人群血尿酸值及其他生化指标。结果维吾尔族人群中高尿酸血症组血尿酸值平均为(473.01±88.11)μmol/L,对照组血尿酸值的平均为(259.43±78.46)μmol/L,病例组体质指数(BMI)、腰臀比、收缩压、舒张压、尿素氮、肌酐、甘油三脂和总胆固醇均高于对照组,差异有统计学意义(均P<0.05)。高尿酸血症组与对照组在代谢性指标(肥胖、高血压、高甘油三酯和高胆固醇)上差异均有统计学意义(均P<0.05)。结论乌鲁木齐市维吾尔族人群中高尿酸血症患者在相关指标及代谢性指标上均高于正常组(肾小球滤过率除外),其中年龄、尿素氮和肌酐可能是高尿酸血症发生肾功能损伤(CKD)的危险因素。
Objective To understand the differences of serum uric acid, blood lipids and the biochemical indexes of renal function between the patients with and without hyperuricemia in Uygur population of Urumqi, Xinjiang. Methods A case-control study was conducted to investigate the prevalence of 986 Uygur patients with hyperuricemia at a hospital affiliated to Urumqi. The average number of Uygur hyperuricemia patients was 1 353 and the average age was 20 to 80 years old. A questionnaire survey and physical examination And blood biochemical detection, statistics and analysis of Uygur population blood uric acid value and other biochemical indicators. Results The mean uric acid value of hyperuricemia group was (473.01 ± 88.11) μmol / L in Uygur population, (259.43 ± 78.46) μmol / L in control group, BMI, The systolic blood pressure, diastolic blood pressure, blood urea nitrogen, creatinine, triglycerides and total cholesterol were higher than those in the control group (P <0.05). Hyperuricemia group and control group in metabolic indicators (obesity, hypertension, high triglyceride and high cholesterol) were statistically significant differences (all P <0.05). Conclusions Urine hyperuricemia patients in Urumqi population are higher than those in normal group (except for glomerular filtration rate) in related indicators and metabolic indexes, among which age, urea nitrogen and creatinine may be the cause of renal dysfunction in hyperuricemia Risk factors for injury (CKD).