本文报告5例严重嗜铬细胞瘤经α-受体阻滞剂治疗后,高血压及发作性症状不但未能控制,发作次数更为频繁,程度加重,甚至出现儿茶酚胺心肌病或神经系统并发症。经急诊手术摘除肾上腺肿瘤后除1例死亡外,余4例迅速恢复。对手术时机、适应证以及危象发生机制进行了讨论。提出了紧急外科处理指征。 In this paper, after treatment with α-blockers in 5 patients with severe pheochromocytoma, the symptoms of hypertension and seizures have not been controlled, and the frequency of episodes has become more frequent and severe. Even catecholamine cardiomyopathy or neurological complications have appeared. . After emergency surgical removal of adrenal tumors, except for 1 death, the remaining 4 cases recovered rapidly. The timing of surgery, the indications, and the mechanism of crisis were discussed. An indication of emergency surgical treatment was proposed.