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为探索中药对女性更年期骨质疏松的防治作用，设计了以滋肝补肾填精的中药复方更年平调冲剂作用于“更年期大鼠”（简称“更年鼠”）的试验。方法是：选用10～15月龄SD大鼠48．只，随机分为6组：先以低钙饲料喂饲和切除双侧卵巢方法制备“更年风”模型，再分别以更年平调冲剂大、中、小剂量，中药阳性对照药更年安和西药阳性对照药己烯雌酚对其治疗，并分别与模型组及3月龄雌性青年大鼠组（8只）相对照，观察更年平调冲剂对“更年鼠”骨质疏松的防治作用。结果表明：更年平调冲剂的大、中剂量组可令“更年鼠”血钙升高（与模型组比较P＜0．01），并使其骨密度、髓质密度、骨小梁计数等指标均有不同程度的改善，与己烯雌酚作用相仿。提示：更年平调冲剂对“更年鼠”骨质疏松有较好的防治作用。
In order to explore the preventive and therapeutic effects of Chinese herbal medicine on menopausal osteoporosis, a trial of “nourishing period rats” (referred to as “climacteric rats”), a traditional Chinese medicine compound “Gengnianping Tiaogan Granule” with Zigan Bushen filling essence, was designed. Method is: use 10 to 15 months old SD rats 48. Only, randomly divided into 6 groups: First, the “Yannianfeng” model was prepared by feeding low-calcium diets and excision of bilateral ovaries, and then the large, medium, and small doses of Gengnianping granules, and the positive control drugs of traditional Chinese medicine were used for another year. Anxiestrol, a positive control drug in western medicine, was used for its treatment, and compared with the model group and the 3-month-old female young rats group (8 rats). The effect of “Gengnian Rat” osteoporosis on the prevention and treatment of “Gengnian Rat” osteoporosis was observed. . The results showed that the large and middle doses of “Gengnianping Tiao Granula” could increase the blood calcium of the “older rats” (compared with the model group, P <0.01), and made the bone density, medulla density, and trabecular bone. Counts and other indicators have improved to varying degrees, and the effect of diethylstilbestrol is similar. Tip: Gengnianpingtiao granules have a better preventive and therapeutic effect on osteoporosis.