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急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)是临床上常见的危重症,治疗措施包括机械通气及药物综合治疗。肺泡表面活性物质(PS)在维持正常的肺功能起着重要作用,业已证明,PS异常与ALI/ARDS的发病有关,给予外源性PS亦可治疗ALI/ARDS。本文就外源性PS在盐酸吸入性ALI/ARDS的第二时相中的疗效及其可能的作用机制做一综述。
Acute lung injury / acute respiratory distress syndrome (ALI / ARDS) is a clinically common critically ill condition and treatments include mechanical ventilation and drug combination therapy. Alveolar surfactant (PS) plays an important role in maintaining normal lung function. It has been demonstrated that PS abnormality is associated with the pathogenesis of ALI / ARDS. Exogenous PS can also treat ALI / ARDS. This article reviews the efficacy and possible mechanism of exogenous PS in the second phase of inhaled ALI / ARDS.