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目的对比分析河北省赞皇县胃癌高、低发区居民血清胃蛋白酶原、胃泌素和幽门螺杆菌抗体变化，以探讨这些指标与胃癌发生是否有关。方法以放免和ＥＬＩＳＡ方法对赞皇县胃癌高发区和相对低发区９２９名居民的血清胃蛋白酶原Ⅰ、Ⅱ、胃泌素和血清幽门螺杆菌抗体进行了对比分析。结果赞皇县胃癌高发区和相对低发区居民血清平均胃蛋白酶原Ⅰ、Ⅱ、Ⅰ／Ⅱ比值的中位数分别为５４．１μｇ／Ｌ、１２．９μｇ／Ｌ、４．４和５４．５μｇ／Ｌ、１２．３μｇ／Ｌ、４．５，两地区无明显差异；胃癌高发区居民血清胃泌素水平明显高于相对低发区（８５ｐｇ／ｍｌ∶６８ｐｇ／ｍｌ，Ｐ＜０．０１）；两地居民幽门螺杆菌感染均较普遍，胃癌高发区和相对低发区居民血清抗幽门螺杆菌抗体阳性率比较，差异无显著性（Ｐ＞０．０５）。结论除胃泌素外，赞皇县胃癌高发区和相对低发区居民血清胃蛋白酶原Ⅰ、Ⅱ和血清幽门螺杆菌抗体水平均差异无显著性（Ｐ＞０．０５）。
Objective To compare and analyze the changes of serum pepsinogen, gastrin and Helicobacter pylori antibodies in residents with high and low incidence of gastric cancer in Zanhuang County, Hebei Province, in order to investigate whether these indicators are related to the occurrence of gastric cancer. Methods The serum pepsinogen I, II, gastrin and serum Helicobacter pylori antibody of 929 inhabitants in high incidence area and relatively low incidence area in Zanhuang county were analyzed by radioimmunoassay and ELISA. Results The median serum pepsinogen I, II, and I/II ratio in the high-incidence and relatively low-incidence areas of Zanhuang county were 54.1μg/L, 12.9μg/L, 4.4, and 54 respectively. 5μg/L, 12.3μg/L, 4.5, no significant difference between the two regions; serum gastrin levels in residents with high incidence of gastric cancer was significantly higher than the relatively low incidence area (85pg/ml: 68pg/ml, P<0.01 The incidence of Helicobacter pylori infection in the residents of the two places was relatively common. There was no significant difference in the serum anti-H. pylori antibody positive rate between the residents with high incidence of gastric cancer and relatively low incidence areas (P>0.05). Conclusion In addition to gastrin, the serum levels of pepsinogen I, II, and serum Helicobacter pylori antibody in the high-incidence areas and relatively low-risk areas in Zanhuang County were not significantly different (P>0.05).