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目的观察氟伐他汀联合阿司匹林肠溶片治疗老年颈动脉硬化斑块的疗效。方法将68例经颈动脉彩色多普勒检查证实为颈动脉硬化并斑块形成的老年患者随机分为治疗组和对照组各34例,治疗组予以氟伐他汀40mg1/晚联合阿司匹林肠溶片口服治疗;对照组单纯予以阿司匹林肠溶片口服治疗。结果两组治疗后TC、TG、LDL-C、HDL-C等指标差异明显(P<0.05)。两组治疗后动脉硬化斑块、颈动脉内膜厚度的变化差异显著,且具有统计学意义(P<0.05)。治疗组2例出现转氨酶轻度增高,再次复查后正常,无肌痛、横纹肌溶解等严重不良反应发生。结论氟伐他汀联合阿司匹林肠溶片治疗老年颈动脉硬化斑块的疗效显著。
Objective To observe the curative effect of fluvastatin combined with aspirin enteric-coated tablets in treatment of carotid atherosclerosis in the elderly. Methods Seventy-six elderly patients with carotid atherosclerosis and plaque formation confirmed by carotid color Doppler were randomly divided into treatment group and control group, 34 cases each. The treatment group was given fluvastatin 40mg / night combined with aspirin enteric-coated tablets Oral treatment; the control group was treated with aspirin enteric-coated tablets orally. Results After treatment, TC, TG, LDL-C, HDL-C and other indicators were significantly different (P <0.05). There was significant difference in the changes of intima-media thickness between atherosclerotic plaques and carotid arteries after treatment (P <0.05). In the treatment group, 2 cases showed slight increase of aminotransferase, normal again after re-examination, and no serious adverse reactions such as myalgia and rhabdomyolysis occurred. Conclusion The combination of fluvastatin and aspirin enteric-coated tablet has significant therapeutic effect on carotid atherosclerotic plaques in the elderly.