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应用 HBV-DNA 斑点杂交、SPRIA 及 ELISA 等方法检测新生儿出生48小时内外周血 HBV 标志,50名 HBsAg 阳性母亲的新生儿中,HBsAg 阳性5名(10%),抗-HBc 阳性48名(96%),抗-HBs 和抗-HBcIgM 均阴性。34名 HBeAg(ID)阳性母亲的婴儿中,具有 HBV 子宫内感染血清学标志者3名(8.82%)。SPRIA 检测 HBsAg 是目前诊断新生儿 HBV 感染较为敏感的方法。介绍新生儿HBV 子宫内感染的临床特点。
The HBV markers of newborns within 48 hours after birth were detected by HBV-DNA dot blot, SPRIA and ELISA. Among the 50 HBsAg positive mothers, 5 (10%) were HBsAg positive and 48 were anti-HBc 96%), both anti-HBs and anti-HBcIgM were negative. Among 34 infants with HBeAg (ID) positive mothers, 3 (8.82%) had HBV intrauterine infection serological markers. SPRIA detection of HBsAg is the current diagnosis of neonatal HBV infection is more sensitive method. Introduction of neonatal HBV intrauterine infection clinical features.