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目的探讨胃底腺息肉(fundic gland polyp,FGP)患者的临床及病理特点。方法回顾性分析312例FGP患者临床资料,包括临床表现、组织病理特点和幽门螺旋杆菌感染情况。结果 312例FGP中男女比例为1∶1.89,其中149例有长期服用质子泵抑制剂药物史;患者临床表现无明显特异性,病变主要分布于胃体及胃底,形态多为山田Ⅱ型,病变直径多为0.2~0.5cm,单发息肉占52.88%;组织病理学示胃腺体大量增生,壁细胞及主细胞增生,胃小凹短浅或缺如,偶伴黏膜急慢性炎症,被覆上皮及腺上皮细胞未见肠化及异型增生表现;幽门螺旋杆菌感染率为19.55%(61/312)。结论 FGP多见于女性,其发生可能与长期口服质子泵抑制剂有关,与幽门螺旋杆菌感染无明显相关性;胃底及胃体病变以山田Ⅱ型为主,胃体腺大量增生为其主要组织病理特点。
Objective To investigate the clinical and pathological features of fundic gland polyp (FGP). Methods A retrospective analysis of 312 cases of FGP clinical data, including clinical manifestations, histopathological features and Helicobacter pylori infection. Results The ratio of male to female in 312 cases of FGP was 1: 1.89, of which 149 cases had prolonged use of proton pump inhibitor drug. The clinical manifestations of the patients were not obviously specific. The lesions mainly distributed in the gastric body and the stomach fundus, Pathological diameter of more than 0.2 ~ 0.5cm, single polyps accounted for 52.88%; histopathology showed a large number of gastric gland hyperplasia, parietal cells and the main cell hyperplasia, short peritubular pits or missing, accompanied by acute and chronic mucosal inflammation, covered epithelium And glandular epithelial cells without intestinal metaplasia and dysplasia; Helicobacter pylori infection rate was 19.55% (61/312). Conclusions FGP is more common in women and its occurrence may be related to long-term oral proton pump inhibitor and no significant correlation with Helicobacter pylori infection. The gastric fundus and gastric body lesions are mainly Yamada type Ⅱ, and the body corpus gland is heavily proliferated into its major tissues Pathological features.